FYI...Dementia and Alzheimers

Maggot

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From what Ive learned, apparently the plaque causes the brain to 'dry out' and eating a lot of foods rich in healthy oils, like salmon(y), and sardines 🤮 keeps it lubricated and slows or even prevents that happening. Not vetted so take it for what its worth. Interesting site, click on Alzheimers and Dementia then follow the same link. The tour of the brain is fascinating.

And no I dont have it. ;)

https://alz.org/alzheimers-dementia/


 

Spblademaker

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Best part of having them is that you’ll never remember you do.
 
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DevilDocAZ

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Its a controversial statement but I'll say it.... amyloid plaques are no more of an indicator of Alzheimer's than grey hair. Plenty of research has been done on healthy people who have amyloid plaques.

But you don't have to take my word for it, just go get some florbetapir injected followed by a PET Scan and see your own amyloid plaque levels.

Your money is prob better spent on Carbon 11 to have that prostate checked. Not as fun as a finger up the butt though.
 

powdahound76

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It is evil. Watched it destroy my grandma who lived 6 blocks away my whole childhood. And how that affected my grandad. An honorable and classy man by her side till the end. 17 yrs from when family started to notice the signs ......

My grandma would still sing along or hum to hymns until about the last year. She was non-verbal for the last 3 except for that.
A DNR for years and no feeding or any artificial anything. She just had a body that way outlived her brain.

And I still like the jokes because we all have a good chance of it if we live that long.
 

W54/XM-388

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Just last week a drug company was called out on the carpet for covering up the fact that one of their cheap drugs for other stuff actually helps prevent Dementia and Alzheimer's... they were suppressing it because it was too cheap and would ruin their expensive not working drug market.


There is a lot of very promising off label stuff that has been shown to work well, but nobody wants to talk about because it's too cheap.

 

Dougie308

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My dad has taken Metformin for years. He’s still in his own reality.

Just last week a drug company was called out on the carpet for covering up the fact that one of their cheap drugs for other stuff actually helps prevent Dementia and Alzheimer's... they were suppressing it because it was too cheap and would ruin their expensive not working drug market.


There is a lot of very promising off label stuff that has been shown to work well, but nobody wants to talk about because it's too cheap.

 

DellaDog

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Took my mom at 80. The last 5 years were pure misery.
Truly wouldn’t wish this disease on anyone. BIL is a brain scientist for ELI Lilly who devoted years to studying plaque and how to slow, stall or reverse the buildup. Nothing came of it.
 

BLKWLFK9

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It's on both sides of my family. Im terrified of getting it. If I ever learn of early onset, I'm icing myself out in the woods with a 12ga. I know all too well of what those diseases do to the surrounding family. I refuse to do that knowingly. I honestly feel that losing someone to death is easier than to one of these diseases.
 

powdahound76

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Find a way to make it less messy. That will seriously fuck with a family member (or anyone else) who finds you.

I spent years in a small community helping to coroner zip body bags because the other firemen couldnt handle it. Its not good for most folks.
 
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DevilDocAZ

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Just last week a drug company was called out on the carpet for covering up the fact that one of their cheap drugs for other stuff actually helps prevent Dementia and Alzheimer's... they were suppressing it because it was too cheap and would ruin their expensive not working drug market.


There is a lot of very promising off label stuff that has been shown to work well, but nobody wants to talk about because it's too cheap.

We had a really interesting talk about this the other day in the lab. Metformin is turning into a designer drug and is being hevily abused. It does have some very interesting anti ageing implications. It artificially boosts AMPK but this just takes advantage of a long known fact.....caloric restriction does lead to longer life.

Literally the "have your cake and eat it" drug.

I guess it's 2019 and everyone wants to take the easy way. Here, have this pill, eat whatever you want.
 

DevilDocAZ

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Took my mom at 80. The last 5 years were pure misery.
Truly wouldn’t wish this disease on anyone. BIL is a brain scientist for ELI Lilly who devoted years to studying plaque and how to slow, stall or reverse the buildup. Nothing came of it.
Sorry for your loss. I wonder if I worked with your BIL on that project. Might have been around thentime they acquired Amyvid. I worked so hard on that project only to find out we chased the wrong thing.

The research wasn't a complete failure. We discovered AV105 and were able to move from c11 (very short halflife...20 min)to an F-18 model with a very useable halflife...but that doesn't make the loss of your mom any easier.

My MIL is in the middle stages. I was cocky and thought I could figure it out.

From the bottom of my heart.....I wanted it to work....for your mom, for my MIL....I'm sorry I let you down.
 

W54/XM-388

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but this just takes advantage of a long known fact.....caloric restriction does lead to longer life.
And further studies showed that caloric restriction makes you hate the idea of a longer life, either for you, or others or you and others.
Your mileage may vary.

I guess it's 2019 and everyone wants to take the easy way. Here, have this pill, eat whatever you want.
You really have to change your diet for it to do any good, cut out all the sugar and get rid of almost all the carbs.
On the plus side, you get to eat fat and protein and vegetables.
 
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Fig

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It's on both sides of my family. Im terrified of getting it. If I ever learn of early onset, I'm icing myself out in the woods with a 12ga. I know all too well of what those diseases do to the surrounding family. I refuse to do that knowingly. I honestly feel that losing someone to death is easier than to one of these diseases.
Instead of that how ‘bout a mission? Manpak nuke into Tehran?
 

Sean the Nailer

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It's on both sides of my family. Im terrified of getting it. If I ever learn of early onset, I'm icing myself out in the woods with a 12ga. I know all too well of what those diseases do to the surrounding family. I refuse to do that knowingly. I honestly feel that losing someone to death is easier than to one of these diseases.
I hear you, and I understand what you're saying. But do me a favor and check out that thread I started last year, called "I'm Smarter Now".....

When I find it, I'll put up a link. Only thing worse for the family is someone eating a 12 gauge AND LIVING and then creating a MASSIVE BURDEN on everyone, every moment of every day from there on after.

Ask me how I know....

And yes, the whole concept of someone LIVING after swallowing a 12 gauge is still incomprehensible to me/us. And yet.....
 

Ric O'shay

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I spent the last two years of my dads life having one sided conversations, because he had no idea who I was and was unable to respond with anything close to reality. I continued to visit him until he withered away.
It was so hard to deal with because he was so strong, vibrant and full of life before the dementia took it all away.
The elder care in this area sucks ass, as they want a passive patient and drug them to avoid the wandering, and occasional outbursts.
I moved him three times, twice he was required to leave because of occasional verbal rages and moving stuff around the facility, he liked to re-arrange the place :)
It was a horrible way to watch a proud man die.
Thank You DevilDoc for trying to find a way to figure that mess out.
 

DellaDog

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Sorry for your loss. I wonder if I worked with your BIL on that project. Might have been around thentime they acquired Amyvid. I worked so hard on that project only to find out we chased the wrong thing.

The research wasn't a complete failure. We discovered AV105 and were able to move from c11 (very short halflife...20 min)to an F-18 model with a very useable halflife...but that doesn't make the loss of your mom any easier.

My MIL is in the middle stages. I was cocky and thought I could figure it out.

From the bottom of my heart.....I wanted it to work....for your mom, for my MIL....I'm sorry I let you down.
You’re a class act DocZ - thanks for your efforts.
You and your colleagues have let no one down.
 

armorpl8chikn

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We had a really interesting talk about this the other day in the lab. Metformin is turning into a designer drug and is being hevily abused. It does have some very interesting anti ageing implications. It artificially boosts AMPK but this just takes advantage of a long known fact.....caloric restriction does lead to longer life.

Literally the "have your cake and eat it" drug.

I guess it's 2019 and everyone wants to take the easy way. Here, have this pill, eat whatever you want.
I've done some study on this recently, specifically AMPK production.
There are other compounds that boost AMPK production better than metformin.
My doctor put me on metformin and I have yet to take any due to some side effects. He seems to think it will help me lose weight. My A1c is elevated, but not to the point that proper diet won't knock it back down.

I've taken a hand full of pills since I was 14 for an unusual kind of hypertension. Unusual being they can't find the cause. So...they throw pills at it, pills that have made weight loss near impossible. I can't live without the pills, and the pills create side effects like gradual weight gain. It is a nasty, depressing cycle. I've lost lots of weight over the years, only to be met by a doctor saying, "Reduce your meds? Why would you want to do that? Your BP is fantastic!"
That's true, but the pills create a wall that no amount of diet and excercise has been able to break. So now...well now with bad knees and ferked up cervical spine.....I've not lost the will to live but I'm tired of fighting that tiger. Besides that I now lack the ability to fight it.

There are no magic pills, the devil is in the details.
 
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Maser

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My last living Great-Grandparent recently celebrated her 90th birthday and she's got the final stage of dementia. She's currently in a rather nice facility because having her live with my family and I just wasn't working out especially after an incident where she pointed a knife at my youngest son in a playful way, but I knew then it was time because she was already getting extremely hard to deal with. We've already had calls from the facility staff saying that she has been belligerent towards the staff and other residence and has been stealing flatware and threatening to kill anyone who goes into her room. It's such a terrible fucking disease to watch happen to a loved one especially one who's been alive so long and essentially has no memory of the past anymore.
 

Maggot

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Sorry for your loss. I wonder if I worked with your BIL on that project. Might have been around thentime they acquired Amyvid. I worked so hard on that project only to find out we chased the wrong thing.

The research wasn't a complete failure. We discovered AV105 and were able to move from c11 (very short halflife...20 min)to an F-18 model with a very useable halflife...but that doesn't make the loss of your mom any easier.

My MIL is in the middle stages. I was cocky and thought I could figure it out.

From the bottom of my heart.....I wanted it to work....for your mom, for my MIL....I'm sorry I let you down.
Doc, thanks for your comments and your work.

I watched my mom go from being belligerent and wandering into the parking lot late at night, to lying in the bed moaning 24/7. A terrible disease.
 

Maggot

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I've done some study on this recently, specifically AMPK production.
There are other compounds that boost AMPK production better than metformin.
My doctor put me on metformin and I have yet to take any due to some side effects. He seems to think it will help me lose weight. My A1c is elevated, but not to the point that proper diet won't knock it back down.

I've taken a hand full of pills since I was 14 for an unusual kind of hypertension. Unusual being they can't find the cause. So...they throw pills at it, pills that have made weight loss near impossible. I can't live without the pills, and the pills create side effects like gradual weight gain. It is a nasty, depressing cycle. I've lost lots of weight over the years, only to be met by a doctor saying, "Reduce your meds? Why would you want to do that? Your BP is fantastic!"
That's true, but the pills create a wall that no amount of diet and excercise has been able to break. So now...well now with bad knees and ferked up cervical spine.....I've not lost the will to live but I'm tired of fighting that tiger. Besides that I now lack the ability to fight it.

There are no magic pills, the devil is in the details.
Sad to hear that Chikn.
 

BLKWLFK9

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I hear you, and I understand what you're saying. But do me a favor and check out that thread I started last year, called "I'm Smarter Now".....

When I find it, I'll put up a link. Only thing worse for the family is someone eating a 12 gauge AND LIVING and then creating a MASSIVE BURDEN on everyone, every moment of every day from there on after.

Ask me how I know....

And yes, the whole concept of someone LIVING after swallowing a 12 gauge is still incomprehensible to me/us. And yet.....
Right, i definitely hear that. But like i had said, I would go out into the woods and do it. If the blast dont do it, i'll bleed the fuck out. My wife works on the psych unit at our local hospital. She's seen gun suicide survivors, and it is horrendous.
 

chevy_man

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Right, i definitely hear that. But like i had said, I would go out into the woods and do it. If the blast dont do it, i'll bleed the fuck out. My wife works on the psych unit at our local hospital. She's seen gun suicide survivors, and it is horrendous.

I thought it would be fun to go base jumping or sky diving, but not bother with the whole parachute thing. Just find a nice deserted spot and splat.

I'm not suicidal, but I'm not going to spend years making everyone miserable as I waste away.
 
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1J04

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From what Ive learned, apparently the plaque causes the brain to 'dry out' and eating a lot of foods rich in healthy oils, like salmon(y), and sardines 🤮 keeps it lubricated and slows or even prevents that happening. Not vetted so take it for what its worth. Interesting site, click on Alzheimers and Dementia then follow the same link. The tour of the brain is fascinating.

And no I dont have it. ;)

https://alz.org/alzheimers-dementia/



You're obviously in denial!
 
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Jefe's Dope

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Took my maternal grandmother at around 70. You can imagine my relief when my mother has outlived her mother, In years living, currently 74, and has not shown any signs of it. Until recently, her memory seems to be affected. I hope it's just her being her and not the disease.
 

Tazman

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Unfortunatly I am attending my moms funeral tomorrow for this issue. 4 years ago she knew who I was, 2 years ago she had no idea and was violent sometimes. I try to just remember her the way she use to be and treat the other as just another pain in the ass!!lol

I told my wife if I ever get that sick that she needs to find a way to help me...…..she said I had a cough the other day and started the process????:unsure:
 

Maggot

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Unfortunatly I am attending my moms funeral tomorrow for this issue. 4 years ago she knew who I was, 2 years ago she had no idea and was violent sometimes. I try to just remember her the way she use to be and treat the other as just another pain in the ass!!lol
:( Sorry to hear that. THats all you can do. It wasnt her anymore, it was just whats left. RIP, Mom.
 

Unknown

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Some times the dementia happens really fast. An older female family member (95) went from able to converse, enjoying knitting, watching TV, and interest in other people, to combative, falling on the floor and not remembering how she got there, and fighting with people who were trying to help her. This deterioration took place over 7-10 days, and she is now in end of life hospice. I think her systems just gave out all at once. I could talk to here on the phone one day, and the next day, she was no longer who she used to be.

In much the same way that too much alcohol intake reduces peoples normal inhibition to say things like "that dress makes your ass look big", or "I always hated that haircut", the same loss of inhibitions seems to happen to lots of older folks.
 

jcm331

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We had a really interesting talk about this the other day in the lab. Metformin is turning into a designer drug and is being hevily abused. It does have some very interesting anti ageing implications. It artificially boosts AMPK but this just takes advantage of a long known fact.....caloric restriction does lead to longer life.

Literally the "have your cake and eat it" drug.

I guess it's 2019 and everyone wants to take the easy way. Here, have this pill, eat whatever you want.
Devil doc I'm sending you a pm, I'm curious about your research
 

jrhtx

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My last living Great-Grandparent recently celebrated her 90th birthday and she's got the final stage of dementia. She's currently in a rather nice facility because having her live with my family and I just wasn't working out especially after an incident where she pointed a knife at my youngest son in a playful way, but I knew then it was time because she was already getting extremely hard to deal with. We've already had calls from the facility staff saying that she has been belligerent towards the staff and other residence and has been stealing flatware and threatening to kill anyone who goes into her room. It's such a terrible fucking disease to watch happen to a loved one especially one who's been alive so long and essentially has no memory of the past anymore.
Please stay on top of this situation. We went through this with my mom. She was in a "Memory Care Facility" in the Houston area after we could no longer provide care at home. We received a call one day from the facility director and were told mom had become unmanageable and we had 1 week to find her a new place to care for her. We were like WTF? We were told they could provide care under any and all conditions. Well that wasn't the case.

When we found a new facility they get all the prior files and information (read now you will be paying a higher facility and care cost!). When mom declined and was moved on hospice, we were told again they could no longer care for her as they were using morphine to calm her and injections were not allowed. She passed less that 10 days later.

Many of these facilities, in this area anyway, are owned by attorneys and the rules are written in their favor. Don't depend on what the staff tells you, it probably isn't true. They will throw her/you out for any reason.
 

Mwalex

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Dementia rips away all dignity from the person that has the illness. My great grandmother had it for over 15 years before she died. My grandmother is 84 and still pretty sharp but she lost a sister to dementia. My mother was a nut bag her entire life for a series of reasons. It runs in my family and I have noticed my memory has started to slip a good bit over the past few years.

As others have posted if I ever test positive for dementia I will go out on my terms, not wasting away and a burden for someone.
 

clcustom1911

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It's a hell of a disease. I respond to calls all the time about it. Both in cop mode and Paramedic mode.

My maternal grandfather passed from it. A "man's man", Navy Commander, tribologist for Standard Oil. Didn't know who I was the last time I saw him before he passed just after I finished the police academy.

Like a few said before, I'm going out on my terms and refuse to be a burden on anyone. With my lifestyle (living to the fullest, murica) and high-risk careers, if I make it to 80, I'll be shocked.

"Better to burn out than fade away"

-Patrick McNamara
 

svthuh

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Watched my maternal G.Grandmother die from it. It was terrible. Last real memory I have of her was when I was 14 or so, I was sitting next to her in the assisted living home and she was talking to me, fully aware of who I was, then looked at my mom not 5 seconds later and asked when I was going to come visit her. Freaked me out. At least she went down quick and slipped into a coma and passed peacefully. She didn't go through all the violence and belligerence like many do.

My maternal Grandmother has surpassed my G.Grandmother in age, but she's battling a completely different animal now. She was diagnosed with Leukemia 3 months ago and is requiring blood and platelet transfusions every few weeks now. Getting old is a fucked up process. Meanwhile, my Grandfather is 93 years old, has a hard time walking after his double hip/knee replacements (tile setter his whole life), but is sharp as a tack. He gave up on life when he began struggling with mobility and just keeps trudging along. But at least he knows who he is and who we are. We are all happy about that.
 

Maggot

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It's a hell of a disease. I respond to calls all the time about it. Both in cop mode and Paramedic mode.

My maternal grandfather passed from it. A "man's man", Navy Commander, tribologist for Standard Oil. Didn't know who I was the last time I saw him before he passed just after I finished the police academy.

Like a few said before, I'm going out on my terms and refuse to be a burden on anyone. With my lifestyle (living to the fullest, murica) and high-risk careers, if I make it to 80, I'll be shocked.

"Better to burn out than fade away"

-Patrick McNamara
With all respect to your Grandpaw, that was Neil Young.

I figure the way to go, so no one has to clean up the mess, is to write of a letter that will take a couple days to arrive, row way out into the ocean, lean way back, and make sure the pill hits the medula ooblongata. Sharks will take care of the rest. Clean, no muss no fuss.

 
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Mwalex

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"Though getting a drug out of the lab phases of development and into actual human trials can takes decades and is often tremendously expensive"

This is one thing that needs to change with respect to drug testing. This might not be applicable to every drug test but there are certainly some that should be fast tracked.
 

hollowoutadime

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As others have posted if I ever test positive for dementia I will go out on my terms, not wasting away and a burden for someone.
Im with you on this. In addition I did all the paperwork in case its from an accident.

My mom passed 3 weeks ago from this. I said my goodbyes when she had to be moved into a facility 18 months ago. Still visited, but she didnt know it. This has been tough on Dad after 62yrs of marriage. Hospice was wonderful. They helped out for the last 4 months, and also let all know what to expect.
 

svthuh

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Lost in Idaho...
"Though getting a drug out of the lab phases of development and into actual human trials can takes decades and is often tremendously expensive"

This is one thing that needs to change with respect to drug testing. This might not be applicable to every drug test but there are certainly some that should be fast tracked.
Sign me up here!
 
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Threadcutter308

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Im with you on this. In addition I did all the paperwork in case its from an accident.

My mom passed 3 weeks ago from this. I said my goodbyes when she had to be moved into a facility 18 months ago. Still visited, but she didnt know it. This has been tough on Dad after 62yrs of marriage. Hospice was wonderful. They helped out for the last 4 months, and also let all know what to expect.
Condolences, thoughts and prayers to you and your family.