I run a Dillon 650 and like it- when it's up and running! But, changing calibers takes me anywhere from 45 minutes to an hour. Plus, I always have something major to adjust/fix about every 500 or so rounds when in use. Since you will be doing several calibers, my vote is for the Hor LNL. You can change calibers in about 45 seconds, vs 45 minutes to an hour for the 650. So, caliber change is a big deciding factor, IMO.
I would get the the LNL with the bushings set up in the calibers you mention, and get a case feeder. There are several auto bullet feeders out there that will more than double your output. I can run about 450 rounds an hour loading 223 on a 650 (no bullet feeder) going at a steady pace, more than double with handgun rounds (with the bullet feeder).
Chad, I don't see how it could possibly take 45 minutes to change calibers on a 650. I could see 45 minutes for a 1050, including switching the primer system, but not on a 650. There are two pins you pull out by hand to change the toolhead, and two allen screws to remove while changing the shellplate. A few plastic bushings and the casefeed plate finish it off. 10 minutes is more than enough time, and 5 isn't too hard.
However, I don't like the many plastic parts used on the Dillon 650. There IS always something that always seems to need fixing, especially after a caliber change. I am looking into the Hornady for this reason.